Amniotic Membrane Patch for Ophthalmic use 

Ophthalmology 

• Corneal Ulcers and Burns: Amnio-Patch is utilized to treat corneal ulcers, chemical burns, and other ocular surface disorders. Its properties promote healing and reduce inflammation.

• Pterygium Surgery: Amnio-Patch is used as a graft in pterygium surgery to reduce recurrence rates.

• Dry Eye Syndrome: The amniotic membrane can help soothe and promote healing in patients suffering from severe dry eye, reducing symptoms and inflammation.

• Socket Surgery:  Amniotic membrane can be used in various types of socket surgeries, particularly for its regenerative and anti-inflammatory properties. Some key applications include:

• Post-Extraction Socket Healing – Amniotic membrane can be placed in extraction sockets to accelerate healing and reduce fibrosis.

• Anophthalmic Socket Reconstruction – In cases of socket contracture, amniotic membrane grafts help restore conjunctival surfaces and improve prosthetic fitting.

• Forniceal Reconstruction – Used to repair forniceal shortening caused by scarring or symblepharon formation, improving socket depth and mobility.

• Ocular Surface Repair – Cryopreserved umbilical amniotic membrane (cUAM) has been explored for ocular surface reconstruction, including cicatricial entropion and conjunctival defects

Reference:

Gomes JA, Romano A, Santos MS, Dua HS. Amniotic membrane use in ophthalmology. Curr Opin Ophthalmol. 2005 Aug;16(4):233-40. doi: 10.1097/01.icu.0000172827.31985.3a. PMID: 16000896.

Stefaniu GI, Chiotoroiu SM, Secureanu FA, Purcarea VL, Zemba M. Use of amniotic membrane in bullous keratopathy palliative care. J Med Life. 2014;7 Spec No. 2(Spec Iss 2):88-91. PMID: 25870682; PMCID: PMC4391353.

Kassem RR, El-Mofty RMA. Amniotic Membrane Transplantation in Strabismus Surgery. Curr Eye Res. 2019 May;44(5):451-464. doi: 10.1080/02713683.2018.1562555. Epub 2019 Jan 28. PMID: 30575427

Agarwal R, Nagpal R, Todi V, Sharma N. Descemetocele. Surv Ophthalmol. 2021 Jan-Feb;66(1):2-19. doi: 10.1016/j.survophthal.2020.10.004. Epub 2020 Oct 13. PMID: 33058926..

Sabater AL, Perez VL. Amniotic membrane use for management of corneal limbal stem cell deficiency. Curr Opin Ophthalmol. 2017 Jul;28(4):363-369. doi: 10.1097/ICU.0000000000000386. PMID: 28426442.

Furdova A, Czanner G, Koller J, Vesely P, Furda R, Pridavkova Z. Amniotic membrane application in surgical treatment of conjunctival tumors. Sci Rep. 2023 Feb 17;13(1):2835. doi: 10.1038/s41598-023-30050-y. PMID: 36808170; PMCID: PMC9938263.

Sharma R, Nappi V, Empeslidis T. The developments in amniotic membrane transplantation in glaucoma and vitreoretinal procedures. Int Ophthalmol. 2023 May;43(5):1771-1783. doi: 10.1007/s10792-022-02570-5. Epub 2023 Jan 30. PMID: 36715957; PMCID: PMC10149474.

Amniotic Membrane Disc for Ophthalmic use

Ophthalmology 

• Corneal Ulcers and Burns: Amnio-Disc is utilized to treat corneal ulcers, chemical burns, and other ocular surface disorders. Its properties promote healing and reduce inflammation.

• Pterygium Surgery: Amnio-Disc is used as a graft in pterygium surgery to reduce recurrence rates.

• Dry Eye Syndrome: The amniotic membrane can help soothe and promote healing in patients suffering from severe dry eye, reducing symptoms and inflammation.

• Sizes 6mm, 8mm, 10mm

• Gamma Sterile 

Reference:

Gomes JA, Romano A, Santos MS, Dua HS. Amniotic membrane use in ophthalmology. Curr Opin Ophthalmol. 2005 Aug;16(4):233-40. doi: 10.1097/01.icu.0000172827.31985.3a. PMID: 16000896.

Sharma R, Nappi V, Empeslidis T. The developments in amniotic membrane transplantation in glaucoma and vitreoretinal procedures. Int Ophthalmol. 2023 May;43(5):1771-1783. doi: 10.1007/s10792-022-02570-5. Epub 2023 Jan 30. PMID: 36715957; PMCID: PMC10149474.

Amniotic Membrane Patch  for chronic wound healing

Wound Healing

• Chronic Wounds: Amnio-Patch is applied to diabetic foot ulcers, venous ulcers, and pressure sores. It promotes healing through anti-inflammatory effects and supports cellular proliferation.

• Burn Treatment: Amnio-Patch offers a biologically active dressing for partial-thickness and full-thickness burns, promoting faster healing and minimizing scarring. 

• Surgical Wounds: Amnio-Patch  can be used to cover surgical incisions to enhance healing and minimize scar formation.

Reference:

Dai C, Shih S, Khachemoune A. Skin substitutes for acute and chronic wound healing: an updated review. J Dermatolog Treat. 2020 Sep;31(6):639-648. doi: 10.1080/09546634.2018.1530443. Epub 2020 Jan 30. PMID: 30265595.

Hofmann N, Rennekampff HO, Salz AK, Börgel M. Preparation of human amniotic membrane for transplantation in different application areas. Front Transplant. 2023 May 5;2:1152068. doi: 10.3389/frtra.2023.1152068. PMID: 38993896; PMCID: PMC11235369.

McQuilling JP, Carter MJ, Fulton JA, Patel K, Doner B, Serena TE, Mowry KC. A prospective clinical trial evaluating changes in the wound microenvironment in patients with chronic venous leg ulcers treated with a hypothermically stored amniotic membrane. Int Wound J. 2022 Jan;19(1):144-155. doi: 10.1111/iwj.13606. Epub 2021 May 6. PMID: 33955178; PMCID: PMC8684864.

Ruiz-Cañada C, Bernabé-García Á, Liarte S, Rodríguez-Valiente M, Nicolás FJ. Chronic Wound Healing by Amniotic Membrane: TGF-β and EGF Signaling Modulation in Re-epithelialization. Front Bioeng Biotechnol. 2021 Jul 6;9:689328. doi: 10.3389/fbioe.2021.689328. PMID: 34295882; PMCID: PMC8290337.

Mirzadegan E, Golshahi H, Kazemnejad S. Current evidence on immunological and regenerative effects of menstrual blood stem cells seeded on scaffold consisting of amniotic membrane and silk fibroin in chronic wound. Int Immunopharmacol. 2020 Aug;85:106595. doi: 10.1016/j.intimp.2020.106595. Epub 2020 May 23. PMID: 32454419.

Amniotic Membrane Patch  for Dental use

Dental Applications

• Periodontal Procedures: Amnio-Patch is used in periodontal surgeries for guided tissue regeneration and to enhance soft tissue healing around teeth and implants.

• Oral Mucosa Repair: Amnio-Patch applications help in the treatment of oral lesions and ulcers due to its healing properties.

Reference:

Kumar Periyasamy I, Mehthaf A, Elangovan GP, D V, Vijaykumar G, Elumalai A. Efficacy of Amniotic and Chorionic Membrane in Facial Wound Healing: A Comparative Study. Cureus. 2024 Apr 12;16(4):e58160. doi: 10.7759/cureus.58160. PMID: 38741866; PMCID: PMC11089579.

Hazarika K, Malik K, Adhyapok AK, Debnath SC. Lyophilised Amniotic Membrane in Intraoral Surgical Defects: A Prospective Clinical Study. Ann Maxillofac Surg. 2022 Jan-Jun;12(1):5-10. doi: 10.4103/ams.ams_152_21. Epub 2022 Aug 16. PMID: 36199459; PMCID: PMC9527846.

Samandari MH, Tamizifar A, Hosseinian M, Adibi S, Razavi SM. Amniotic membrane as an accelator in mandibular bone defects repair. Dent Res J (Isfahan). 2023 Jan 18;20:13. PMID: 36820136; PMCID: PMC9937928.

Bakhtiar H, Ashoori A, Rajabi S, Pezeshki-Modaress M, Ayati A, Mousavi MR, Ellini MR, Kamali A, Azarpazhooh A, Kishen A. Human amniotic membrane extracellular matrix scaffold for dental pulp regeneration in vitro and in vivo. Int Endod J. 2022 Apr;55(4):374-390. doi: 10.1111/iej.13675. Epub 2021 Dec 29. PMID: 34923640.

Tsuno H, Noguchi M, Okabe M, Tomihara K, Yoshida T, Nikaido T. Use of hyperdry amniotic membrane in operations for cleft palate: a study in rats. Br J Oral Maxillofac Surg. 2015 Apr;53(4):358-63. doi: 10.1016/j.bjoms.2015.01.018. Epub 2015 Feb 14. PMID: 25684075.

Fujiwara K, Tsuno H, Okabe M, Yoshida T, Imaue S, Tomihara K, Arai N, Noguchi M. Clinical Application of Hyperdry Amniotic Membrane in Cleft Palate Repair. Cleft Palate Craniofac J. 2023 Jun;60(6):701-705. doi: 10.1177/10556656221075937. Epub 2022 Feb 28. PMID: 35225019.

Kumar KA, Chakravarthy M, Selvarajan S, Ramakrishnan T, Ari G. Use of an amniotic membrane as a novel barrier in a tooth with a questionable prognosis. J Indian Soc Periodontol. 2017 May-Jun;21(3):237-240. doi: 10.4103/jisp.jisp_67_16. PMID: 29440793; PMCID: PMC5803882.

Amniotic Membrane Patch for Orthopedic use

Orthopedics

• Soft Tissue Repair: Amnio-Patch can be used in the treatment of tendon injuries, muscle repairs, and ligament reconstruction, aiding in healing and reducing inflammation.

• Cartilage Repair: Studies are exploring the use of AM in cartilage defect repair due to its ability to support cell growth.

• Regenerative Medicine

• Tissue Engineering: Amnio-Patch serves as a scaffold in tissue engineering, where it promotes cell proliferation and differentiation, aiding in the creation of new tissues.

• Immunology

• Immune Modulation: The bioactive components in Amnio-Patch may help modulate immune responses, making it useful in treating autoimmune conditions or graft-versus-host disease.

Reference::

Forbes J, Jackson GR, Knapik DM, Childers JT, Donley C, Coutelle N, Sabesan VJ. The use of amniotic tissue-derived products in orthopedic surgery: A narrative review. Injury. 2024 Nov;55(11):111901. doi: 10.1016/j.injury.2024.111901. Epub 2024 Sep 19. PMID: 39341049.

Doudi S, Barzegar M, Taghavi EA, Eini M, Ehterami A, Stokes K, Alexander JS, Salehi M. Applications of acellular human amniotic membrane in regenerative medicine. Life Sci. 2022 Dec 1;310:121032. doi: 10.1016/j.lfs.2022.121032. Epub 2022 Oct 5. PMID: 36206834.

Bhattacharjee M, Escobar Ivirico JL, Kan HM, Shah S, Otsuka T, Bordett R, Barajaa M, Nagiah N, Pandey R, Nair LS, Laurencin CT. Injectable amnion hydrogel-mediated delivery of adipose-derived stem cells for osteoarthritis treatment. Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2120968119. doi: 10.1073/pnas.2120968119. PMID: 35046053; PMCID: PMC8794776.

Shahrokh Shahraki S, Yavari M, Tabrizi A. Effect of Amniotic Membrane Nerve Wrapping in Final Results of Traumatic Peripheral Nerve Repair. World J Plast Surg. 2022 Jul;11(2):90-94. doi: 10.52547/wjps.11.2.90. PMID: 36117898; PMCID: PMC9446123.

Riboh JC, Saltzman BM, Yanke AB, Cole BJ. Human Amniotic Membrane-Derived Products in Sports Medicine: Basic Science, Early Results, and Potential Clinical Applications. Am J Sports Med. 2016 Sep;44(9):2425-34. doi: 10.1177/0363546515612750. Epub 2015 Nov 19. PMID: 26585668.

McClendon DC, Su J, Smith DW. Human Amniotic Allograft in Hand Surgery. J Hand Surg Am. 2023 Apr;48(4):388-395. doi: 10.1016/j.jhsa.2022.11.001. Epub 2022 Dec 17. PMID: 36535838.

Amniotic Membrane Patch for Dermatology use

Dermatology

• Skin Grafting: Amnio-Patch can serve as a biological dressing or skin substitute in reconstructive surgery and in patients with skin defects or injuries.

• Psoriasis and Eczema: AM applications have been studied for inflammatory skin conditions, providing relief through its anti-inflammatory properties.

Reference:

Lo V, Pope E. Amniotic membrane use in dermatology. Int J Dermatol. 2009 Sep;48(9):935-40. doi: 10.1111/j.1365-4632.2009.04173.x. PMID: 19702975.

Ilic D, Vicovac L, Nikolic M, Lazic Ilic E. Human amniotic membrane grafts in therapy of chronic non-healing wounds. Br Med Bull. 2016 Mar;117(1):59-67. doi: 10.1093/bmb/ldv053. Epub 2016 Jan 12. PMID: 26764358.

Garcia N, Jiminez V, Graham L, Huang C. Unique Usages of Dehydrated Human Amnion Chorion Membrane Allografts in Dermatology. J Drugs Dermatol. 2023 Dec 1;22(12):1228-1231. doi: 10.36849/JDD.7115. PMID: 38051836.

Bourgeois M, Loisel F, Obert L, Pluvy I, Gindraux F. Can the amniotic membrane be used to treat peripheral nerve defects? A review of literature. Hand Surg Rehabil. 2019 Sep;38(4):223-232. doi: 10.1016/j.hansur.2019.05.006. Epub 2019 Jun 8. PMID: 31185315.

Musa M, Chukwuyem E, Enaholo E, Esekea I, Iyamu E, D'Esposito F, Tognetto D, Gagliano C, Zeppieri M. Amniotic Membrane Transplantation: Clinical Applications in Enhancing Wound Healing and Tissue Regeneration. Adv Exp Med Biol. 2025;1479:39-58. doi: 10.1007/5584_2024_834. PMID: 39514052.

Nejad AR, Hamidieh AA, Amirkhani MA, Sisakht MM. Update review on five top clinical applications of human amniotic membrane in regenerative medicine. Placenta. 2021 Jan 1;103:104-119. doi: 10.1016/j.placenta.2020.10.026. Epub 2020 Oct 22. PMID: 33120046.